Obesity can be inherited

We inherit obesity through gene mutations.

Eight genes are tested  to help answer some of your questions relating to genes and obesity.

Questions such as

  • Your genetic predisposition to obesity
  • Is obesity caused by fat, in your case?
  • Is obesity caused by carbohydrates, in your case?
  • How strong is the Yoyo-Effect in your case?
  • Is fat deposited around your organs?
  • How intense is your hunger?
  • How intense is your satiety?
  • Do you tend to have a diet particularly rich in calories, due to your genes?
  • Do you tend to eat several small snacks, because of your genes?
  • How effective is calorie reduction (eating less) for losing weight?
  • How much muscle mass do you lose by a reduction in calories?
  • What relationship between strength and endurance sports is recommended for you?
  • What can you eat without problems and what should you avoid?

How much influence do genes have on body weight?

According to research there is a heritable component to BMI and fat mass.

Several studies found that the genetic component of overweight or fat mass seems to be between 20% and 90%.

-In a family studies that compared a parent-child and sibling correlations, heritability estimates fall in the range of 20% to 80%.

-In twins studies, heritability estimates fall in the range of  50% to 90%

-In an analysis of over 3.500 twin pairs who were 4 years old,

shared  environmental factors accounted for 24 percent of variance in weight adjusted for height in boys,and, 25 percent of the variance in girls.

*Note: The effects of all genes can be measured, but you cannot identify the genes responsible for them.

The genes we analyze are certainly only just a part of the estimated 20 % to 90% heritability.

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More info about some of the genes we test

– FTO gene and fat sensitivity: people who take in a lot of fat and carry the unfavorable gene variation of this gene have a BMI of about 2.4 points higher than people who take in a lot of fat and have the favorable gene variant. This is a difference of approx. 18 lbs!

– PPARG gene and influence on fat sensitivity: people with the unfavorable gene variant who had a particularly high fat intake through their food, had an average of 1.9 BMI points more than persons with the favorable gene variant who had a particularly high fat intake through the food. This is a 15 lbs difference!

– PPARG gene Influence on weight reduction with calorie reduction and exercise: people with the favorable genetic variation lost 4.9% more weight than people with the unfavorable genetic variations.

– ADRB3 gene Influence on weight reduction through exercise: People with the unfavorable gene variant, who exercise have a 2.98-fold higher risk (298%) of becoming overweight.

– ADRB3 gene Influence on exercise and calorie reduction: People with the unfavorable gene variant lost 1.6lbs less weight than people with the favorable gene variant.

– APOA5 gene Influence on weight reduction efficiency: People with the favorable gene variant reduced their BMI by 13.4%, while people with the unfavorable gene variant reduced their BMI by 0.4% with the same effort.

– APOA2 gene and fat sensitivity: People who take in a lot of fat and have the unfavorable gene variant have on average a 6.2% higher BMI than people who take in a lot of fat and carry the favorable gene variant. This is again a variation of about 14 lbs!

 

References

//www.ncbi.nlm.nih.gov/pubmed/15996212

//www.ncbi.nlm.nih.gov/pubmed/12917707

//www.ncbi.nlm.nih.gov/pubmed/12406043

//diabetes.diabetesjournals.org/content/51/8/2581.long

//www.ncbi.nlm.nih.gov/pubmed/14506127

//www.ncbi.nlm.nih.gov/pmc/articles/PMC3223879/

//www.ncbi.nlm.nih.gov/pubmed/19901143

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